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Structures important for the epithelial integrity and function involve the basement membrane, the semipermeable sheet on which the cells rest, and interdigitations, as well as cellular junctions

In MPTP-induced dopaminergic neurotoxicity in mice, two structural analogs of CDDO (TP-319 and TP-500), which are produced by the cyclization of squalene, have been shown to increase bloodbrain barrier permeability and provide protection against inflammation and oxidative stress [118]